Cannabis ( continued)

Delta9- tetrahydrocannabinol is the primary psychoactive constituent of cannabis and acts as agonists at both CB1 and CB 2 receptors.

It activates presynapticCB1 receptors decreasing cyclic AMP synthesis with downstream functional effects resulting in reduced neurotransmission.

Clinically the effects observed are impaired learning,memory,spatial orientation and attention during cannabis intoxication.

Delta 9 THC can cause tachycardia,low BP,dry mouth and dry eyes.

It's use does not result in respiratory depression observed with benzodiazepine or opioids administration as CB 1 receptors are not found in medullary respiratory centres.

Delta9 THC exhibits both analgesic and anti inflammatory properties.

CannabidiolCBD lacks the intoxicating properties or the high of THC.

It demonstrates weak affinity for CB1 and CB2 receptors.CBD may have indirect effects at CB1 receptors but not with CB 2.

CBD has ANticonvulsant,anti anxiety,anti inflammatory and heuroprotective properties.

The presence of CBD product in Cannabis is believed to moderate or counteract psychosis inducing effects of THC.

Other names of mine phytocannabinoids are,

Cannabigerol has antibacterial properties.

Tetrahydrocannabivarin has antiepileptic effects.

Synthetic Cannabinoids

Dronabinol,identical to THC 

Na lions,a THC analogue

These have been used for nausea,vomitting,appetite stimulation,pain,spasticity.

Recreational use of illegally synthesised cannabinoid receptor agonists are sold in the market as Black Mamba,crazy clown,K-2,spice

These agents of abuse are associated with psychosis,agitation,vomitting and death.

List of conditions for which medical cannabis is used are,

1.Alzeimers

2. ALS

3.cachexia

4.cancer

5.Crohns disease

6.seizures and epilepsy

7. Glaucoma

8. HepatitisC

9.AIDS

10.MS to reduce spasticity

11. Chronic pain

12.Nausea

13. PTSD

I want to thank Mayo clinic for educating us with authentic information about medical cannabis.