Cannabis ( continued)

Delta9- tetrahydrocannabinol is the primary psychoactive constituent of cannabis and acts as agonists at both CB1 and CB 2 receptors.

It activates presynapticCB1 receptors decreasing cyclic AMP synthesis with downstream functional effects resulting in reduced neurotransmission.

Clinically the effects observed are impaired learning,memory,spatial orientation and attention during cannabis intoxication.

Delta 9 THC can cause tachycardia,low BP,dry mouth and dry eyes.

It's use does not result in respiratory depression observed with benzodiazepine or opioids administration as CB 1 receptors are not found in medullary respiratory centres.

Delta9 THC exhibits both analgesic and anti inflammatory properties.

CannabidiolCBD lacks the intoxicating properties or the high of THC.

It demonstrates weak affinity for CB1 and CB2 receptors.CBD may have indirect effects at CB1 receptors but not with CB 2.

CBD has ANticonvulsant,anti anxiety,anti inflammatory and heuroprotective properties.

The presence of CBD product in Cannabis is believed to moderate or counteract psychosis inducing effects of THC.

Other names of mine phytocannabinoids are,

Cannabigerol has antibacterial properties.

Tetrahydrocannabivarin has antiepileptic effects.

Synthetic Cannabinoids

Dronabinol,identical to THC 

Na lions,a THC analogue

These have been used for nausea,vomitting,appetite stimulation,pain,spasticity.

Recreational use of illegally synthesised cannabinoid receptor agonists are sold in the market as Black Mamba,crazy clown,K-2,spice

These agents of abuse are associated with psychosis,agitation,vomitting and death.

List of conditions for which medical cannabis is used are,

1.Alzeimers

2. ALS

3.cachexia

4.cancer

5.Crohns disease

6.seizures and epilepsy

7. Glaucoma

8. HepatitisC

9.AIDS

10.MS to reduce spasticity

11. Chronic pain

12.Nausea

13. PTSD

I want to thank Mayo clinic for educating us with authentic information about medical cannabis.

Cannabis

Cannabis is classified as Medical or Recreational.

Now we will discuss about Medical Cannabis or Medical marihuana.

It is a group of pharmacological agents derived from subspecies of flowering plant genus cannabis .

It is used with intent of alleviating a symptom or a condition.

Medical Cannabis can be delivered in a variety of ways e.g inhaled,swallowed,topical application to skin or bu cal mucosa.

DEA calls it Schedule1 drug.

Currently 30 states and District of Columbia have programs authorizing cannabis use for medical conditions.

As Cannabis is illegal under federal law,clinicians cannot prescribe it and pharmacies cannot dispense it.

States require clinicians to be registered to certify patients for cannabis use.

Clinicians who certify are protected against federal legal repercussions.

Some states require clinicians to have ongoing relationship with patients as needing history and physicals on these patients.

Cannabis is supplied to patients through state licensed dispensaries.

These are for profit centers selling any prep or production compliance with state law.

However we do not know quality as this is not regulated by FDA.

Most states allow access to dried flowers or whole plant cannabis.

None of this is covered by insurance.

Endocannabinoid system

Cannabis interacts with endocannabinoid system.

The endocannabinoid system is a network of receptors that send signals.

The type 1 cannabinoid receptor CB1 is highly expressed in the central nervous system concentrated in prefrontal cortex,basal ganglia,hippocampus,amYgdala,hypothalamus and cerebellum.

Retro synaptic gammaaminobutyric acid signaling generates the neuropsychiatric effects of cannabis.

CB1 receptors are also found in smooth muscle,myocardium,adipocytes,preganglionic symathetic neurons integrated with autonomic and endocrine systems.

The type2 cannabinoid receptorCB2 is expressed in peripheral blood mononuclear cells,macrophages,

 B cells and natural killer cells.CB2 receptors are also present in myocardium,vascular endothelium and

smooth muscle.

Our body synthesises endocannabinoid molecules and they are,

1.N- Arachidonoylethanolamine (AEA or Anandamide)

2.  2-arachidonoylglycerol

Both of these are agonists at CB1 and CB2 receptors.

Phytocannabinoids

These are naturally occurring molecules with affinity for cannabinoid receptors.Over 100 photo cannabinoid pd have been isolated from cannabis.

Concentrations of these cannabinoids in cannabis depend on cannabis strain and horticultural techniques.

Eat to beat disease

I wanted to share an important information with you all.

We all eat bread.However it is found that sourdough bread has more benefits than others and is a good choice.

It has been determined by studies that Lactobacillus reuteri the bacteria used for culture has important 

health benefits in improving immunity,signalling gut brain axis to release oxytocin which is a bonding or socializing hormone.

It also helps weight loss,suppress tumor development,speed up wound healing.

Vow! Eat your choice of bread and reap the benefits.